Teigo Asai

Profile Information

Affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University

Degree: 博士 (理学)(Mar, 2011, 東京工業大学)

J-GLOBAL ID: 201101025343013271
researchmap Member ID: 6000028078

Research Areas

Research History

Oct, 2019 - Present

Professor, Graduate School of Pharmaceutical Sciences, Tohoku University
Mar, 2016 - Sep, 2019

Department of Life Sciences, Graduate School of Arts and Sicences, The University of Tokyo
Jul, 2009 - Feb, 2016

Assistant Professor, Graduate School of Pharmaceutical Sciences, Tohoku University

Papers

Genome mining of labdane-related diterpenoids: Discovery of the two-enzyme pathway leading to (−)-sandaracopimaradiene in the fungus Arthrinium sacchari

Fumito Sato, Terutaka Sonohara, Shunta Fujiki, Akihiro Sugawara, Yohei Morishita, Taro Ozaki, Teigo Asai

Beilstein Journal of Organic Chemistry, Apr 3, 2024 Peer-reviewed
A new 3,6-dialkyl-α-pyrone produced by the heterologous expression of a PKS-NRPS hybrid enzyme derived from a Pestalotiopsis endophyte

Yue Shi, Taro Ozaki, Akihiro Sugawara, Yohei Morishita, Yu Pei Tan, Roger G. Shivas, Rohan A. Davis, Teigo Asai

Tetrahedron Letters, 134 154865-154865, Jan, 2024
Identification and Functional Characterization of Fungal Chalcone Synthase and Chalcone Isomerase

Sho Furumura, Taro Ozaki, Akihiro Sugawara, Yohei Morishita, Kento Tsukada, Tatsuya Ikuta, Asuka Inoue, Teigo Asai

Journal of Natural Products, 86(2) 398-405, Feb 10, 2023 Peer-reviewedLast authorCorresponding author
Discovery of a Cyclic Depsipeptide from Chaetomium mollipilium by the Genome Mining Approach.

Yuto Homma, Akihiro Sugawara, Yohei Morishita, Kento Tsukada, Taro Ozaki, Teigo Asai

Organic letters, 24(19) 3504-3509, May 20, 2022 Peer-reviewedLast authorCorresponding author
Synthetic Biology-Based Discovery of Diterpenoid Pyrones from the Genome of Eupenicillium shearii.

Yohei Morishita, Kento Tsukada, Kazuma Murakami, Kazuhiro Irie, Teigo Asai

Journal of natural products, 85(2) 384-390, Feb 25, 2022 Peer-reviewedLast authorCorresponding author
Genome Mining-Based Discovery of Fungal Macrolides Modified by glycosylphosphatidylinositol (GPI)-Ethanolamine Phosphate Transferase Homologues.

Yohei Morishita, Yu Aoki, Mei Ito, Daisuke Hagiwara, Kensho Torimaru, Daichi Morita, Teruo Kuroda, Hanako Fukano, Yoshihiko Hoshino, Masato Suzuki …

Organic letters, 22(15) 5876-5879, Jul 14, 2020 Peer-reviewedLast authorCorresponding author
Synthetic-biology-based discovery of a fungal macrolide from Macrophomina phaseolina.

Yohei Morishita, Terutaka Sonohara, Tohru Taniguchi, Kiyohiro Adachi, Makoto Fujita, Teigo Asai

Organic & biomolecular chemistry, 18(15) 2813-2816, Apr 15, 2020 Peer-reviewedLast authorCorresponding author
Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones.

Kento Tsukada, Shono Shinki, Akiho Kaneko, Kazuma Murakami, Kazuhiro Irie, Masatoshi Murai, Hideto Miyoshi, Shingo Dan, Kumi Kawaji, Hironori Hayashi …

Nature communications, 11(1) 1830-1830, Apr 14, 2020 Peer-reviewedLast authorCorresponding author
Correction: Synthetic-biology-based discovery of a fungal macrolide from Macrophomina phaseolina

Yohei Morishita, Terutaka Sonohara, Tohru Taniguchi, Kiyohiro Adachi, Makoto Fujita, Teigo Asai

Organic & Biomolecular Chemistry, 18(17) 3392-3392, 2020
The Discovery of Fungal Polyene Macrolides via a Postgenomic Approach Reveals a Polyketide Macrocyclization by trans-Acting Thioesterase in Fungi.

Yohei Morishita, Huiping Zhang, Tohru Taniguchi, Keiji Mori, Teigo Asai

Organic letters, 21(12) 4788-4792, Jun 21, 2019 Peer-reviewedLast authorCorresponding author
Post-genomic approach based discovery of alkylresorcinols from a cricket-associated fungus, Penicillium soppi

Akiho Kaneko, Yohei Morishita, Kento Tsukada, Tohru Taniguchi, Teigo Asai

ORGANIC & BIOMOLECULAR CHEMISTRY, 17(21) 5239-5243, Jun, 2019 Peer-reviewedLast authorCorresponding author
Use of plant hormones to activate silent polyketide biosynthetic pathways in Arthrinium sacchari, a fungus isolated from a spider

Yohei Morishita, Yusuke Okazaki, Yi Yi Luo, Jun Nunoki, Tohru Taniguchi, Yoshiteru Oshima, Teigo Asai

ORGANIC & BIOMOLECULAR CHEMISTRY, 17(4) 780-784, Jan, 2019 Peer-reviewedLast authorCorresponding author
Pazopanib-induced crystal deposition in intestinal mucosa in a patient with retroperitoneal liposarcoma

Shigemitsu Horie, Hayato Nishida, Toshihiko Sakurai, Osamu Ichiyanagi, Tomoyuki Kato, Makoto Yagi, Takanobu Kabasawa, Teigo Asai, Norihiko Tsuchiya

INTERNATIONAL JOURNAL OF UROLOGY, 25(6) 627-629, Jun, 2018 Peer-reviewed
Natural Product Chemistry based on Isolation and Structure Elucidation

Teigo Asai

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 76(5) 406-409, May, 2018 Peer-reviewed
[The application of epigenetic regulation for natural products discovery].

Teigo Asai, Yoshiteru Oshima

Seikagaku. The Journal of Japanese Biochemical Society, 88(5) 643-8, Oct, 2016 Peer-reviewed
A Lanthipeptide-like N-Terminal Leader Region Guides Peptide Epimerization by Radical SAM Epimerases: Implications for RiPP Evolution

Sebastian W. Fuchs, Gerald Lackner, Brandon I. Morinaka, Yohei Morishita, Teigo Asai, Sereina Riniker, Jorn Piel

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 55(40) 12330-12333, Sep, 2016 Peer-reviewed
Isolation and identification of an endophytic fungus from Erythronium japonicum Decne and inhibitory effect of secondary metabolites on carcinoma cells

Qun Lu, Teigo Asai, Yoshiteru Oshima

Modern Food Science and Technology, 32(1) 22-28, Jan 15, 2016 Peer-reviewed
Epigenetic stimulation of polyketide production in Chaetomium cancroideum by an NAD(+)-dependent HDAC inhibitor

Teigo Asai, Shuntaro Morita, Tohru Taniguchi, Kenji Monde, Yoshiteru Oshima

ORGANIC & BIOMOLECULAR CHEMISTRY, 14(2) 646-651, 2016 Peer-reviewedLead authorCorresponding author
Use of a biosynthetic intermediate to explore the chemical diversity of pseudo-natural fungal polyketides

Teigo Asai, Kento Tsukada, Satomi Ise, Naoki Shirata, Makoto Hashimoto, Isao Fujii, Katsuya Gomi, Kosuke Nakagawara, Eiichi N. Kodama, Yoshiteru Oshima

NATURE CHEMISTRY, 7(9) 737-743, Sep, 2015 Peer-reviewedLead authorCorresponding author
生物間相互作用

浅井禎吾, 大島吉輝

ファルマシア, 50(2) 156_1-156_1, 2014

Misc.

Biosynthetic study of pestalactams

SHI Yue, 菅原章公, 尾崎太郎, 浅井禎吾

日本薬学会年会要旨集(Web), 143rd, 2023
Biosynthetic study on chaetophenols produced by a fungus Chaetomium indicum

松井洸人, 塚田健人, 菅原章公, 尾崎太郎, 浅井禎吾

日本薬学会年会要旨集(Web), 143rd, 2023
Genome mining-based discovery of fungal macrolides from Aspergillus petrakii

LI Yi, 菅原章公, 尾崎太郎, 浅井禎吾

日本薬学会年会要旨集(Web), 143rd, 2023
Biosynthetic study of hymeglusin

廣川瑞樹, 森下陽平, 塚田健人, 菅原章公, 尾崎太郎, 浅井禎吾

日本薬学会年会要旨集(Web), 143rd, 2023
Structure elucidation and biosynthetic study of chaetodepsipeptins

本間悠人, 菅原章公, 森下陽平, 塚田健人, 尾崎太郎, 浅井禎吾

日本薬学会年会要旨集(Web), 143rd, 2023
Characterization of the diterpene cyclases involved in the biosynthesis of Vinigrol

佐藤史都, 森下陽平, 塚田健人, 古村翔, 菅原章公, 永田隆平, 葛山智久, 尾崎太郎, 浅井禎吾

日本薬学会年会要旨集(Web), 143rd, 2023
Aspergillus petrakii由来マクロライド生合成遺伝子クラスターの機能解析

李屹, 森下陽平, 菅原章公, 尾崎太郎, 浅井禎吾

日本薬学会東北支部大会講演要旨集, 62nd, 2023
麹菌を宿主とするグリチルリチン生産系の構築

平林薫歩, 尾崎太郎, 森下陽平, 菅原章公, 浅井禎吾

日本薬学会東北支部大会講演要旨集, 62nd, 2023
大規模ゲノム再編成を利用した糸状菌休眠遺伝子活性化研究

天井涼太, 森下陽平, 河野宏光, 尾崎太郎, 菅原章公, 太田邦史, 浅井禎吾

日本薬学会東北支部大会講演要旨集, 62nd, 2023
アマトキシン類の異種生産系確立のためのプラットフォーム構築

根岸透子, 尾崎太郎, 菅原章公, 森下陽平, 浅井禎吾

日本薬学会東北支部大会講演要旨集, 62nd, 2023
糸状菌フラボノイド・クロロフラボニン生合成機構の解析と異種生産

古村翔, 尾崎太郎, 菅原章公, 森下陽平, 浅井禎吾

日本生薬学会年会講演要旨集, 69th, 2023
アマトキシン類の生合成解明に向けた遺伝子資源の探索

根岸透子, 尾崎太郎, 菅原章公, 森下陽平, 浅井禎吾

日本生薬学会年会講演要旨集, 69th, 2023
Vinigrol骨格形成機構の解明を目指した環化中間体の網羅的な単離構造決定

佐藤史都, 森下陽平, 塚田健人, 古村翔, 菅原章公, 尾崎太郎, 浅井禎吾

日本生薬学会年会講演要旨集, 69th, 2023
糸状菌デプシペプチドのポストゲノム型探索研究

本間悠人, 菅原章公, 森下陽平, 塚田健人, 尾崎太郎, 浅井禎吾

日本薬学会東北支部大会講演要旨集, 61st, 2022
ゲノムマイニングによる糸状菌マクロライド類の探索

李屹, 菅原章公, 尾崎太郎, 浅井禎吾

日本薬学会東北支部大会講演要旨集, 61st, 2022
Atranone類およびMyrocin類の生合成におけるジテルペン環化酵素の機能解析

佐藤史都, 園原照隆, 森下陽平, 菅原章公, 尾崎太郎, 浅井禎吾

日本薬学会東北支部大会講演要旨集, 61st, 2022
chaetophenol類の生合成研究

松井洸人, 塚田健人, 青木優, 菅原章公, 尾崎太郎, 浅井禎吾, 浅井禎吾

日本薬学会東北支部大会講演要旨集, 61st, 2022
Study on funiculosin biosynthesis

小此木亮介, 菅原章公, 尾崎太郎, 浅井禎吾

日本薬学会年会要旨集(Web), 142nd, 2022
Investigation of terpen cyclase in atranone biosynthesis

佐藤史都, 園原照隆, 森下陽平, 菅原章広, 尾崎太郎, 浅井禎吾

日本薬学会年会要旨集(Web), 142nd, 2022
Genome mining of UbiA-type sesqui terpene cyclases

倉澤岳志, 園原照隆, 菅原章公, 尾崎太郎, 浅井禎吾

日本薬学会年会要旨集(Web), 142nd, 2022

Professional Memberships

日本薬学会

Research Projects

合成生物学的手法を基盤とする活性天然物の構造展開研究

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2022 - Mar, 2026

浅井禎吾
大規模ゲノム再編成を基盤とする革新的天然物創製法の開発

科学研究費助成事業挑戦的研究(萌芽), 挑戦的研究(萌芽), 日本学術振興会, Jul, 2021 - Mar, 2024

浅井禎吾
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Jun, 2020 - Mar, 2023
Development of therapeutics for intractable infections using diverse natural products combined with stress-inductive biosynthesis and chemical modification

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Kodama Eiichi
糸状菌未開拓マクロライド生合成経路の再構築と再設計による新規抗生物質シーズの開拓

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2019 - Mar, 2021

浅井禎吾
Discovery of novel peptide natural product with anti bacterial activities

Grants-in-Aid for Scientific Research Challenging Research (Exploratory), Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2018 - Mar, 2021

Teigo Asai
Post-genomic natural discovery focused on unique polyketide synthase genes

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A), Grant-in-Aid for Young Scientists (A), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2021

Asai Teigo
麹菌異種発現系を基盤とする人工代謝経路の構築と抗がん活性擬天然物の創生研究

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2017 - Mar, 2019

浅井禎吾
Novel screenings for unmet medical needs with innovative new natural product derived compounds

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Kodama Eiichi
Generation of new drug seed natural products from entomopathogenic microorganism by activating silent biosynthetic gene clusters

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

ASAI Teigo
新規生合成マシナリー開拓を志向した未利用遺伝子活性化による天然物構造多様性の創出

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2013 - Mar, 2015

浅井禎吾
Production of novel fungal secondary metabolites by epigenetically activating the silent biosynthetic gene clusters.

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2011 - 2012

ASAI Teigo

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Misc.

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