Takiko Daikoku

Profile Information

Affiliation: Research Center for Experimental Modeling of Human Disease, Kanazawa University

J-GLOBAL ID: 201801000347444985
researchmap Member ID: B000303477

Research Interests

Research Areas

Research History

Apr, 2021 - Present

Professor, Division of Animal Disease Model, Research Center for Experimental Modeling of Human Disease, Kanazawa University
Jun, 2015 - Mar, 2021

Advanced Science Research Center, Kanazawa University
Sep, 2011 - Jun, 2015

Research Associate Professor, Division of Reproductive Sciences, Cincinnati Children’s Hospital Medical Center, USA
May, 2008 - Aug, 2011

Research Assistant Professor, Division of Reproductive Sciences, Cincinnati Children’s Hospital Medical Center, USA
Mar, 2004 - May, 2008

Research Assistant Professor, Department of Pediatrics, Vanderbilt University Medical Center, USA
Jul, 2002 - Feb, 2004

Postdoctoral Fellow, Department of Pediatrics, Vanderbilt University Medical Center, USA
Sep, 2001 - Jun, 2002

Postdoctoral Fellow, Department of Molecular and Integrative, University of Kansas Medical Center, USA
Apr, 2000 - Sep, 2001

Postdoctoral Fellow, Department of Biochemistry, University of Kansas Medical Center, USA

Education

Apr, 1997 - Mar, 2000

The University of Tokushima
Apr, 1995 - Mar, 1997

The University of Tokushima
Apr, 1991 - Mar, 1995

Faculty of Pharmaceutical Sciences, The University of Tokushima

Committee Memberships

Major Papers

Spheroid formation induces chemokine production in trophoblast-derived Swan71 cells.

Tatsuhito Kanda, Kyosuke Kagami, Takashi Iizuka, Haruki Kasama, Takeo Matsumoto, Yuya Sakai, Takuma Suzuki, Megumi Yamamoto, Ayumi Matsuoka, Rena Yamazaki …

American journal of reproductive immunology (New York, N.Y. : 1989), 90(2) e13752, Aug, 2023 Peer-reviewed
Androgen promotes squamous differentiation of atypical cells in cervical intraepithelial neoplasia via an <scp>ELF3</scp>‐dependent pathway

Takeo Matsumoto, Takuma Suzuki, Mitsuhiro Nakamura, Megumi Yamamoto, Takashi Iizuka, Masanori Ono, Kyosuke Kagami, Haruki Kasama, Tatsuhito Kanda, Yuya Sakai …

Cancer Medicine, 12(9) 10816-10828, Mar 23, 2023 Peer-reviewedCorresponding author
<scp>FOXP4</scp> inhibits squamous differentiation of atypical cells in cervical intraepithelial neoplasia via an <scp>ELF3</scp>‐dependent pathway

Takeo Matsumoto, Takashi Iizuka, Mitsuhiro Nakamura, Takuma Suzuki, Megumi Yamamoto, Masanori Ono, Kyosuke Kagami, Haruki Kasama, Kousho Wakae, Masamichi Muramatsu …

Cancer Science, 113(10) 3376-3389, Aug, 2022 Corresponding author
Uterine Deletion of Bmal1 Impairs Placental Vascularization and Induces Intrauterine Fetal Death in Mice

Masanori Ono, Natsumi Toyoda, Kyosuke Kagami, Takashi Hosono, Takeo Matsumoto, Shin-ichi Horike, Rena Yamazaki, Mitsuhiro Nakamura, Yasunari Mizumoto, Tomoko Fujiwara …

International Journal of Molecular Sciences, 23(14), Jul, 2022 Peer-reviewedCorresponding author
Immunosuppressive tumor microenvironment in Uterine Serous Carcinoma via CCL7 signal with myeloid-derived suppressor cells.

Yuka Mise, Junzo Hamanishi, Takiko Daikoku, Shiro Takamatsu, Taito Miyamoto, Mana Taki, Koji Yamanoi, Ken Yamaguchi, Masayo Ukita, Naoki Horikawa …

Carcinogenesis, 43(7) 647-658, Mar 30, 2022 Peer-reviewed
A novel oral inhibitor for one-carbon metabolism and checkpoint kinase 1 inhibitor as a rational combination treatment for breast cancer.

Jin Lee, Xiaoxi Chen, Yuming Wang, Tatsunori Nishimura, Mengjiao Li, Satoko Ishikawa, Takiko Daikoku, Junya Kawai, Arinobu Tojo, Noriko Gotoh

Biochemical and biophysical research communications, 584 7-14, Dec 20, 2021 Peer-reviewed
Mucinous, endometrioid, and serous ovarian cancers with peritoneal dissemination are potent candidates for P-cadherin targeted therapy: a retrospective cohort study.

Kayo Kayahashi, Yasunari Mizumoto, Ayumi Matsuoka, Takeshi Obata, Junpei Iwadare, Mitsuhiro Nakamura, Takiko Daikoku, Hiroshi Fujiwara

BMC cancer, 21(1) 32-32, Jan 7, 2021 Peer-reviewed
Promoting Roles of Embryonic Signals in Embryo Implantation and Placentation in Cooperation with Endocrine and Immune Systems.

Hiroshi Fujiwara, Masanori Ono, Yukiyasu Sato, Kazuhiko Imakawa, Takashi Iizuka, Kyosuke Kagami, Tomoko Fujiwara, Akihito Horie, Hirohiko Tani, Akira Hattori …

International journal of molecular sciences, 21(5), Mar 10, 2020 Peer-reviewed
The Association and Significance of p53 in Gynecologic Cancers: The Potential of Targeted Therapy.

Mitsuhiro Nakamura, Takeshi Obata, Takiko Daikoku, Hiroshi Fujiwara

International journal of molecular sciences, 20(21), Nov 4, 2019 Peer-reviewed
IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma.

Satoshi Kofuji, Akiyoshi Hirayama, Alexander Otto Eberhardt, Risa Kawaguchi, Yuki Sugiura, Oltea Sampetrean, Yoshiki Ikeda, Mikako Warren, Naoya Sakamoto, Shuji Kitahara …

Nature cell biology, 21(8) 1003-1014, Aug, 2019 Peer-reviewed
Ovarian insufficiency and CTNNB1 mutations drive malignant transformation of endometrial hyperplasia with altered PTEN/PI3K activities.

Terakawa J, Serna VA, Taketo MM, Daikoku T, Suarez AA, Kurita T

Proceedings of the National Academy of Sciences of the United States of America, Feb, 2019 Peer-reviewed
Novel strategy of ovarian cancer implantation: Pre-invasive growth of fibrin-anchored cells with neovascularization

Ayumi Matsuoka, Yasunari Mizumoto, Masanori Ono, Kyosuke Kagami, Takeshi Obata, Junpei Terakawa, Yoshiko Maida, Mitsuhiro Nakamura, Takiko Daikoku, Hiroshi Fujiwara

Cancer Science, 110(8) 2658-2666, 2019 Peer-reviewed
The uterine epithelial loss of Pten is inefficient to induce endometrial cancer with intact stromal Pten.

Liang X, Daikoku T, Terakawa J, Ogawa Y, Joshi AR, Ellenson LH, Sun X, Dey SK

PLoS genetics, 14(8) e1007630, Aug, 2018 Peer-reviewedLead author
Crosstalk between PKCα and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium.

Hsu AH, Lum MA, Shim KS, Frederick PJ, Morrison CD, Chen B, Lele SM, Sheinin YM, Daikoku T, Dey SK …

Cell reports, 24(3) 655-669, Jul, 2018 Peer-reviewed
Factors Regulating Human Extravillous Trophoblast Invasion: Chemokine-peptidase and CD9-integrin Systems.

Hiroshi Fujiwara, Hisanori Matsumoto, Yukiyasu Sato, Akihito Horie, Masanori Ono, Mitsuhiro Nakamura, Yasunari Mizumoto, Kyosuke Kagami, Tomoko Fujiwara, Akira Hattori …

Current pharmaceutical biotechnology, 19(10) 764-770, 2018 Peer-reviewed
Dual expression of immunoreactive estrogen receptor beta and p53 is a potential predictor of regional lymph node metastasis and postoperative recurrence in endometrial endometrioid carcinoma

Takeshi Obata, Mitsuhiro Nakamura, Yasunari Mizumoto, Takashi Iizuka, Masanori Ono, Jumpei Terakawa, Takiko Daikoku, Hiroshi Fujiwara

PLOS ONE, 12(11) e0188641, Nov, 2017 Peer-reviewed
Dual Positive Regulation of Embryo Implantation by Endocrine and Immune Systems - Step-by-Step Maternal Recognition of the Developing Embryo

Hiroshi Fujiwara, Yoshihiko Araki, Kazuhiko Imakawa, Shigeru Saito, Takiko Daikoku, Minoru Shigeta, Hideharu Kanzaki, Takahide Mori

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 75(3) 281-289, Mar, 2016 Peer-reviewed
The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis

Kazutaka Sumita, Yu-Hua Lo, Koh Takeuchi, Miki Senda, Satoshi Kofuji, Yoshiki Ikeda, Jumpei Terakawa, Mika Sasaki, Hirofumi Yoshino, Nazanin Majd …

MOLECULAR CELL, 61(2) 187-198, Jan, 2016 Peer-reviewed
The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.

Kazutaka Sumita, Yu-Hua Lo, Koh Takeuchi, Miki Senda, Satoshi Kofuji, Yoshiki Ikeda, Jumpei Terakawa, Mika Sasaki, Hirofumi Yoshino, Nazanin Majd …

Mol. Cell, 61(2) 187-198, Jan, 2016 Peer-reviewed
Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells

Adam Blaisdell, Amandine Crequer, Devin Columbus, Takiko Daikoku, Khush Mittal, Sudhansu K. Dey, Adrian Erlebacher

CANCER CELL, 28(6) 785-799, Dec, 2015 Peer-reviewed
SSK1, a novel GTP-dependent kinase, detects GTP levels and regulates tumorigenesis

Sumita K, Takeuchi K, Lo Y, Senda M, Kofuji S, Ikeda Y, Yoshino H, Sasaki M, Terakawa J, Daikoku T …

Molecular Biology of the Cell, 26, 2015 Peer-reviewed
Mammalian Target of Rapamycin Complex 1 and Cyclooxygenase 2 Pathways Cooperatively Exacerbate Endometrial Cancer

Takiko Daikoku, Jumpei Terakawa, Md M. Hossain, Mikihiro Yoshie, Monica Cappelletti, Peiying Yang, Lora H. Elenson, Sudhansu K. Dey

AMERICAN JOURNAL OF PATHOLOGY, 184(9) 2390-2402, Sep, 2014 Peer-reviewedLead authorCorresponding author
Lactoferrin-iCre: A New Mouse Line to Study Uterine Epithelial Gene Function

Takiko Daikoku, Yuya Ogawa, Jumpei Terakawa, Akiyo Ogawa, Tony DeFalco, Sudhansu K. Dey

ENDOCRINOLOGY, 155(7) 2718-2724, Jul, 2014 Peer-reviewedLead authorCorresponding author
Ovarian LGR5 is critical for successful pregnancy

Xiaofei Sun, Jumpei Terakawa, Hans Clevers, Nick Barker, Takiko Daikoku, Sudhansu K. Dey

FASEB JOURNAL, 28(5) 2380-2389, May, 2014 Peer-reviewedCorresponding author
A review of the potential utility of Mycophenolate Mofetil as a cancer therapeutic.

Majd N, Sumita K, Yoshino H, Chen D, Terakawa J, Daikoku T, Kofuji S, Curry R, Wise-Draper T, Warnick R …

Journal of Cancer Research, ID 423401, 2014 Peer-reviewed
CXCR2-Expressing Myeloid-Derived Suppressor Cells Are Essential to Promote Colitis-Associated Tumorigenesis

Hiroshi Katoh, Dingzhi Wang, Takiko Daikoku, Haiyan Sun, Sudhansu K. Dey, Raymond N. DuBois

CANCER CELL, 24(5) 631-644, Nov, 2013 Peer-reviewed
Conditional deletion of Tsc1 in the female reproductive tract impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice

Takiko Daikoku, Mikihiro Yoshie, Huirong Xie, Xiaofei Sun, Jeeyeon Cha, Lora Hedrick Ellenson, Sudhansu K. Dey

MOLECULAR HUMAN REPRODUCTION, 19(7) 463-472, Jul, 2013 Peer-reviewedLead authorCorresponding author
Cyclocreatine treatment improves cognition in mice with creatine transporter deficiency

Yuko Kurosawa, Ton J. DeGrauw, Diana M. Lindquist, Victor M. Blanco, Gail J. Pyne-Geithman, Takiko Daikoku, James B. Chambers, Stephen C. Benoit, Joseph F. Clark

JOURNAL OF CLINICAL INVESTIGATION, 122(8) 2837-2846, Aug, 2012 Peer-reviewed
Conditional Deletion of MSX Homeobox Genes in the Uterus Inhibits Blastocyst Implantation by Altering Uterine Receptivity

Takiko Daikoku, Jeeyeon Cha, Xiaofei Sun, Susanne Tranguch, Huirong Xie, Tomoko Fujita, Yasushi Hirota, John Lydon, Francesco DeMayo, Robert Maxson …

DEVELOPMENTAL CELL, 21(6) 1014-1025, Dec, 2011 Peer-reviewedLead author
Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice

Yasushi Hirota, Jeeyeon Cha, Mikihiro Yoshie, Takiko Daikoku, Sudhansu K. Dey

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(44) 18073-18078, Nov, 2011 Peer-reviewed
Cell-specific conditional deletion of Pten in the uterus results in differential phenotypes

Takiko Daikoku, Lindsey Jackson, Valerie Besnard, Jeffrey Whitsett, Lora Hedrick Ellenson, Sudhansu K. Dey

GYNECOLOGIC ONCOLOGY, 122(2) 424-429, Aug, 2011 Peer-reviewedLead authorCorresponding author
Uterine FK506-binding protein 52 (FKBP52)-peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress

Yasushi Hirota, Nuray Acar, Susanne Tranguch, Kristin E. Burnum, Huirong Xie, Ako Kodama, Yutaka Osuga, Ismail Ustunel, David B. Friedman, Richard M. Caprioli …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(35) 15577-15582, Aug, 2010 Peer-reviewed
Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice

Yasushi Hirota, Takiko Daikoku, Susanne Tranguch, Huirong Xie, Heather B. Bradshaw, Sudhansu K. Dey

JOURNAL OF CLINICAL INVESTIGATION, 120(3) 803-815, Mar, 2010 Peer-reviewed
CYP1B1 expression in ovarian cancer in the laying hen Gallus domesticus

Yan Zhuge, Jo Ann J. Lagman, Kristine Ansenberger, Cassandra J. Mahon, Takiko Daikoku, Sudhansu K. Dey, Janice M. Bahr, Dale B. Hales

GYNECOLOGIC ONCOLOGY, 112(1) 171-178, Jan, 2009 Peer-reviewed
Two faces of PTEN

Takiko Daikoku, Sudhansu K. Dey

NATURE MEDICINE, 14(11) 1192-1193, Nov, 2008 Peer-reviewedLead author
Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice

Takiko Daikoku, Yasushi Hirota, Susanne Tranguch, Ayesha R. Joshi, Francesco J. DeMayo, John P. Lydon, Lora H. Ellenson, Sudhansu K. Dey

CANCER RESEARCH, 68(14) 5619-5627, Jul, 2008 Peer-reviewedLead author
MicroRNA regulation of cyclooxygenase-2 during embryo implantation

Anindita Chakrabarty, Susanne Tranguch, Takiko Daikoku, Kevin Jensen, Henry Furneaux, Sudhansu K. Dey

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104(38) 15144-15149, Sep, 2007 Peer-reviewed
FKBP52 deficiency-conferred uterine progesterone resistance is genetic background and pregnancy stage specific

Susanne Tranguch, Haibin Wang, Takiko Daikoku, Huirong Xie, David F. Smith, Sudhansu K. Dey

JOURNAL OF CLINICAL INVESTIGATION, 117(7) 1824-1834, Jul, 2007 Peer-reviewed
Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer

Takiko Daikoku, Susanne Tranguch, Anindita Chakrabarty, Dingzhi Wang, Dineo Khabele, Sandra Orsulic, Jason D. Morrow, Raymond N. DuBois, Sudhansu K. Dey

CANCER RESEARCH, 67(11) 5285-5292, Jun, 2007 Peer-reviewedLead author
CXCL1 induced by prostaglandin E-2 promotes angiogenesis in colorectal cancer

DZ Wang, HB Wang, J Brown, T Daikoku, W Ning, Q Shi, A Richmond, R Strieter, SK Dey, RN DuBois

JOURNAL OF EXPERIMENTAL MEDICINE, 203(4) 941-951, Apr, 2006 Peer-reviewed
Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer

T Daikoku, S Tranguch, IN Trofimova, DM Dinulescu, T Jacks, AY Nikitin, DC Connony, SK Dey

CANCER RESEARCH, 66(5) 2527-2531, Mar, 2006 Peer-reviewedLead author
Levels of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase are reduced in inflammatory bowel disease: evidence for involvement of TNF-alpha

T Otani, K Yamaguchi, E Scherl, BH Du, HH Tai, M Greifer, L Petrovic, T Daikoku, SK Dey, K Subbaramaiah …

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 290(2) G361-G368, Feb, 2006 Peer-reviewed
Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation

S Tranguch, J Cheung-Flynn, T Daikoku, Prapapanich, V, MB Cox, HR Xie, HB Wang, SK Das, DF Smith, SK Dey

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(40) 14326-14331, Oct, 2005 Peer-reviewed
Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer

T Daikoku, DZ Wang, S Tranguch, JD Morrow, S Orsulic, RN DuBois, SK Dey

CANCER RESEARCH, 65(9) 3735-3744, May, 2005 Peer-reviewedLead author
Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation

T Hamatani, T Daikoku, HB Wang, H Matsumoto, MG Carter, MSH Ko, SK Dey

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(28) 10326-10331, Jul, 2004 Peer-reviewed
Molecular cues to implantation

SK Dey, H Lim, SK Das, J Reese, BC Paria, T Daikoku, HB Wang

ENDOCRINE REVIEWS, 25(3) 341-373, Jun, 2004 Peer-reviewed
Expression of hypoxia-inducible factors in the peri-implantation mouse uterus is regulated in a cell-specific and ovarian steroid hormone-dependent manner - Evidence for differential function of HIFs during early pregnancy

T Daikoku, H Matsumoto, RA Gupta, SK Das, M Gassmann, RN Dubois, SK Dey

JOURNAL OF BIOLOGICAL CHEMISTRY, 278(9) 7683-7691, Feb, 2003 Peer-reviewed
Cyclooxygenase-2 differentially directs uterine angiogenesis during implantation in mice

H Matsumoto, WG Ma, T Daikoku, XM Zhao, BC Paria, SK Das, JM Trzaskos, SK Dey

JOURNAL OF BIOLOGICAL CHEMISTRY, 277(32) 29260-29267, Aug, 2002 Peer-reviewed
Dramatic enhancement of the specific expression of the heart-type fatty acid binding protein in rat brown adipose tissue by cold exposure.

Daikoku T, Shinohara Y, Shima A, Yamazaki N, Terada H

FEBS letters, 410(2-3) 383-386, Jun, 1997 Peer-reviewedLead author

Misc.

子宮がん発生を制御する分子機構の解明

大黒多希子, 寺川純平, 松岡歩, 水本泰成, 藤原浩

がんと代謝研究会プログラム&抄録集, 8th, 2022
UTERINE-SPECIFIC BMAL1 DELETION DISRUPTS MATERNAL NEOVASCULARIZATION DURING DECIDUALIZATION/PLACENTATION AND LEADS TO MISCARRIAGE DEATH

Masanori Ono, Natsumi Toyoda, Takashi Hosono, Kyosuke Kagami, Jumpei Terakawa, Tomoko Fujiwara, Mieda Michihiro, Hitoshi Ando, Hiroshi Fujiwara, Takiko Daikoku

PLACENTA, 114 141-142, Oct, 2021
子宮上皮Gp130は転写抑制因子Snail1の発現およびエストロゲン応答性の減弱を介してマウス胚着床を誘起する

並木貴文, 唐釜春実, 寺川純平, 大黒多希子, 影山敦子, 長谷川嘉則, 小原収, 伊藤潤哉, 柏崎直巳

日本絨毛性疾患研究会・日本胎盤学会学術集会プログラム・抄録集, 39th-29th, 2021
マウスモデルを用いた子宮がん発生を制御する分子機構の解明

寺川純平, 井之上幸範, 松岡歩, 水本泰成, 藤原浩, 大黒多希子

日本生殖医学会雑誌, 64(3) 110-110, Jul, 2019
A novel mouse model of endometrial cancer: epithelial specific Pten deletion with lactoferrin-iCre

Takiko Daikoku, Jumpei Terakawa, Sudhansu K. Dey

CANCER RESEARCH, 75, Aug, 2015
DISCOVERY OF A p53-INDEPENDENT SUPPRESSOR OF SENESCENCE OF GLIOBLASTOMA MULTIFORME

Kazutaka Sumita, Mindy Davis, Rajan Pragani, Jumpei Terakawa, Takiko Daikoku, Nazanin Majd, Min Shen, Zhuyin Li, Xin Hu, Lewis Cantley …

NEURO-ONCOLOGY, 16, Nov, 2014
Involvement of cAMP Signaling Mediators, Epac1, Epac2 and Rap1 in Decidualization of Rat Uterus

Mikihiro Yoshie, Kazuya Kusama, Kazuhiro Tamura, Takiko Daikoku, Tsutomu Takarada, Eiichi Tachikawa

ENDOCRINE REVIEWS, 35(3), Jun, 2014
Intersection of mTORC1 and COX2 pathways as potential therapeutic targets in a mouse model of endometrial cancer

Takiko Daikoku, Jumpei Terakawa, Sudhansu K. Dey

CANCER RESEARCH, 73, Oct, 2013
Dominant expression of NAD(+)-dependent isocitrate dehydrogenase in brown adipose tissue

K Kajimoto, T Daikoku, N Yamazaki, Y Shinohara, H Terada

MOLECULAR BIOLOGY OF THE CELL, 13 130A-130A, Nov, 2002
Differences in the expression of proteins in white and brown adipose tissues

A Shima, K Kajimoto, T Daikoku, Y Shinohara, N Yamazaki, H Terada

MOLECULAR BIOLOGY OF THE CELL, 12 97A-98A, Nov, 2001

Books and Other Publications

HORMONE FRONTIER IN GYNECOLOGY

(Role: Contributor)

Mar, 2023
ヒトゲノム事典

井ノ上, 逸朗, 今西, 規, 河村, 正二, 斎藤, 成也, 颯田, 葉子, 田嶋, 敦 (Role: Contributor, 25.2 受精卵着床にかかわる遺伝子)

一色出版, Nov, 2021 (ISBN: 9784910389127)

Major Presentations

Bmal1時計遺伝子欠損マウスにおける胎盤形成不全

大黒多希子

第62回日本先天異常学会学術集会, Jul 31, 2022 Invited
子宮がん発生を制御する分子機構の解明

大黒多希子, 寺川純平, 松岡歩, 水本泰成, 藤原浩

第8回がんと代謝研究会 in佐渡, Jul 20, 2022
マウスモデルを用いた子宮体癌発症・進展に対する女性ホルモンの影響についての解析

大黒多希子

第26回日本生殖内分泌学会学術集会, Jan 18, 2022 Invited
マウスモデルを用いた子宮がん発生を制御する分子機構の解明

寺川純平, 井之上幸範, 松岡歩, 水本泰成, 藤原浩, 大黒多希子

日本生殖医学会雑誌, Jul, 2019, (一社)日本生殖医学会
マウスモデルを用いた子宮疾患の解析

大黒多希子

第５８回日本組織細胞科学会総会・学術総会, Sep 24, 2017 Invited
マウスモデルからみる子宮疾患

大黒多希子

第５３回北陸生殖医学会学術講演会, Jun 11, 2017 Invited
マウスモデルを用いた子宮疾患の解析

第６２回日本病理学会秋季特別総会, Nov 11, 2016 Invited
Protein kinase C alpha suppresses AKT activation in endometrial cancer

Alice H. Hsu, Kathryn J. Curry, Kang-Sup Shim, Peter Frederick, Carl D. Morrison, Baojiang Chen, Subodh M. Lele, Takiko Daikoku, Sudhansu K. Dey, Gustavo Leone, Adrian R. Black, Jennifer D. Black

CANCER RESEARCH, Jul, 2016, AMER ASSOC CANCER RESEARCH
Protein kinase C alpha (PKC alpha) regulates PI3K/AKT signaling in endometrial cancer

Alice H. Hsu, Kathryn J. Curry, Kang-Sup Shim, Peter Frederick, Carl Morrison, Baojing Chen, Subodh M. Lele, Takiko Daikoku, Sudhansu K. Dey, Gustavo Leone, Adrian R. Black, Jennifer D. Black

CANCER RESEARCH, Aug, 2015, AMER ASSOC CANCER RESEARCH
A novel mouse model of endometrial cancer: epithelial specific Pten deletion with lactoferrin-iCre

Takiko Daikoku, Jumpei Terakawa, Sudhansu K. Dey

CANCER RESEARCH, Aug, 2015, AMER ASSOC CANCER RESEARCH
DISCOVERY OF A p53-INDEPENDENT SUPPRESSOR OF SENESCENCE OF GLIOBLASTOMA MULTIFORME

Kazutaka Sumita, Mindy Davis, Rajan Pragani, Jumpei Terakawa, Takiko Daikoku, Nazanin Majd, Min Shen, Zhuyin Li, Xin Hu, Lewis Cantley, Matthew Boxer, Anton Simeonov, Atsuo Sasaki

NEURO-ONCOLOGY, Nov, 2014, OXFORD UNIV PRESS INC
Neutrophil recruitment into premalignant lesions differentially influences tumor growth versus progression.

Adam Blaisdell, Takiko Daikoku, Chin Siean Tay, Sudhansu Dey, Adrian Erlebacher

JOURNAL OF IMMUNOLOGY, May, 2014, AMER ASSOC IMMUNOLOGISTS
GTPエネルギーを感知するキナーゼの同定と癌における役割

佐々木敦朗, 竹内恒, 壽美田一貴, LO Yu‐Hua, 千田美紀, 寺川純平, 大黒多希子, CANTLEY Lewis, 千田俊哉

日本分子生物学会年会プログラム・要旨集(Web), 2014
Intersection of mTORC1 and COX2 pathways as potential therapeutic targets in a mouse model of endometrial cancer

Takiko Daikoku, Jumpei Terakawa, Sudhansu K. Dey

CANCER RESEARCH, Oct, 2013, AMER ASSOC CANCER RESEARCH
Increased Mammalian Target of Rapamycin Complex-1 (mTORC1) Signaling Is a Major Contributor to Preterm Birth

Jeeyeon M. Cha, Yasushi Hirota, Takiko Daikoku, Sudhansu K. Dey

REPRODUCTIVE SCIENCES, Mar, 2012, SAGE PUBLICATIONS INC
Potential Combination Therapy to Combat Endometrial Cancer

Takiko Daikoku, Lindsey Jackson, Sudhansu K. Dey

CANCER RESEARCH, Apr, 2011, AMER ASSOC CANCER RESEARCH
COX-1-PPAR delta signaling axis in epithelial ovarian tumor.

T Daikoku, DZ Wang, S Orsulic, RN DuBois, SK Dey

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Nov, 2005, AMER ASSOC CANCER RESEARCH

Teaching Experience

Professional Memberships

2005 - Present

American Association for Cancer Research
2015 - Present

北陸実験動物研究会
2015 - Present

国立大学法人動物実験施設協議会
2016 - Present

北陸生殖医学会

Major Research Projects

閉経後ホルモン依存性子宮体癌の発症・進展の新たな分子機構 -男性ホルモン作用の解析と臨床応用-

革新的がん医療実用化研究事業, 国立研究開発法人日本医療研究開発機構, Apr, 2020 - Mar, 2023
Elucidation of the mutual response of epithelium and stoma that controls cancer initiation with uterine cancer mouse models

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
Analysis of the mechanisms of induction of cancer initiation/progression by abnormal peripheral circadian rhythm using cancer mouse models

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2020 - Mar, 2022

Daikoku Takiko
Identify suppressors of sarcoma initiation with newly established uterine sarcoma mouse model to develop novel molecular targeted therapy

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2018 - Mar, 2020

Daikoku Takiko
マウスモデルを用いた子宮内膜間質肉腫発生機序の解析

研究助成, 公益財団法人北國がん基金, Sep, 2018 - Mar, 2019

大黒多希子
子宮選択的Pten変異による体癌自然発症マウスを用いた増悪因子と作用機序の解析

科学研究補助金基盤研究B, 日本学術振興会, Apr, 2016 - Mar, 2019

大黒多希子
子宮体癌進行への卵巣ホルモンの影響

研究助成, 山口内分泌疾患研究振興財団, Apr, 2016 - Mar, 2017

大黒多希子
In pursuit of Lgr5 regulation and function in the uterus

Pilot and Feasibility Funding, CCHMC Perinatal Institute, Jan, 2010 - Jun, 2011

Takiko Daikoku
Pten-Akt-Cox2 signaling axis in endometrial cancer.

Grant, Ohio Cancer Research Associate, Jan, 2010 - Jun, 2011

大黒多希子
A novel mouse model of endometrium-specific cancer

Grant, Concern Foundation, Jul, 2008 - Jun, 2010

Takiko Daikoku
PPARδ is a Downstream Target of COX-1 Derived Prostaglandins in Ovarian Cancer

Gynecologic Cancer Foundation Awards/Ann Schreiber Ovarian Cancer, Research Grant Gynecologic Cancer Foundation, Jan, 2006 - Jun, 2008

Takiko Daikoku
A Novel Mouse Model of Endometrial-Specific Cancer

Vanderbilt-Ingram Cancer Center Support Grant, Vanderbilt-Ingram Cancer Center Support Grant, Sep, 2007 - May, 2008

大黒多希子
Cyclooxygenase-1 Derived Prostacyclin Enhances Ovarian Cancer via Peroxisome Proliferator-Activated Receptor-delta

American Cancer Society-Institutional Research Grant pilot program, American Cancer Society, Jul, 2004 - Jun, 2005

Takiko Daikoku

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