Madoka Narushima

Profile Information

Affiliation: Associate Professor, Department of Homeostatic Development, National Institute for Physiological Sciences

Degree: Ph.D.

J-GLOBAL ID: 201101007922674575
researchmap Member ID: B000001775

in vivo Ca2+イメージング、in vivoおよびスライスパッチクランプ法を用いて、感覚神経系の発達期可塑性のメカニズムを解明したいと考えています。ドイツ・ミュンヘン工科大学、東京女子医科大学を経て、2017年より生理学研究所・生体恒常性発達研究部門に准教授として着任しました。

Research Interests

Research Areas

Life sciences / Neuroscience - general /

Research History

Apr, 2017 - Present

Associate Professor, Division of Homeostatic Development, National Institute for Physiological Sciences
Nov, 2012 - Mar, 2017

准講師, 東京女子医科大学第一生理学

Awards

2017

the Japan Neuroscience Society Young Investigator Award, Comparison of the role of metabotropic glutamate receptor subtype 1 in developmental refinement of neuronal connectivity between the cerebellum and the sensory thalamus

Papers

Development and experience-dependent modulation of the defensive behaviors of mice to visual threats

Madoka Narushima, Masakazu Agetsuma, Junichi Nabekura

The Journal of Physiological Sciences, 72(1) 5-5, Dec, 2022
Histamine depolarizes rat intracardiac ganglion neurons through the activation of TRPC non-selective cation channels

Aya Sato, Shiho Arichi, Fumiaki Kojima, Toru Hayashi, Tatsuko Ohba, Dennis Lawrence Cheung, Kei Eto, Madoka Narushima, Hideji Murakoshi, Yoshihiro Maruo …

European Journal of Pharmacology, 886 173536-173536, Nov, 2020
The metabotropic glutamate receptor subtype 1 regulates development and maintenance of lemniscal synaptic connectivity in the somatosensory thalamus.

Narushima M, Yagasaki Y, Takeuchi Y, Aiba A, Miyata M

PLoS One, 14(12) e0226820, Dec, 2019 Peer-reviewed
The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent Maintenance of Mature Synaptic Connectivity in the Visual Thalamus

Madoka Narushima, Motokazu Uchigashima, Yuki Yagasaki, Takeshi Harada, Yasuyuki Nagumo, Naofumi Uesaka, Kouichi Hashimoto, Atsu Aiba, Masahiko Watanabe, Mariko Miyata …

NEURON, 91(5) 1097-1109, Sep, 2016 Peer-reviewed
Development of Direction Selectivity in Mouse Cortical Neurons

Nathalie L. Rochefort, Madoka Narushima, Christine Grienberger, Nima Marandi, Daniel N. Hill, Arthur Konnerth

NEURON, 71(3) 425-432, Aug, 2011 Peer-reviewed
Sparsification of neuronal activity in the visual cortex at eye-opening

Nathalie L. Rochefort, Olga Garaschuk, Ruxandra-Iulia Milos, Madoka Narushima, Nima Marandi, Bruno Pichler, Yury Kovalchuk, Arthur Konnerth

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(35) 15049-15054, Sep, 2009 Peer-reviewed
Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum.

Uchigashima M, Narushima M, Fukaya M, Katona I, Kano M, Watanabe M

J Neurosci., 27(14) 3663-3676, Apr, 2007 Peer-reviewed
Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum

Motokazu Uchigashima, Madoka Narushima, Masahiro Fukaya, Istvan Katona, Masanobu Kano, Masahiko Watanabe

JOURNAL OF NEUROSCIENCE, 27(14) 3663-3676, Apr, 2007 Peer-reviewed
Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum

Madoka Narushima, Motokazu Uchigashima, Masahiro Fukaya, Minoru Matsui, Toshiya Manabe, Kouichi Hashimoto, Masahiko Watanabe, Masanobu Kano

JOURNAL OF NEUROSCIENCE, 27(3) 496-506, Jan, 2007 Peer-reviewed
Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling in the striatum

Motokazu Uchigashima, Madoka Narushima, Masahiro Fukaya, Istven Katona, Masanobu Kano, Masahiko Watanabe

NEUROSCIENCE RESEARCH, 58 S75-S75, 2007 Peer-reviewed
Depolarization-induced suppression of inhibition mediated by endocannabinoids at synapses from fast-spiking interneurons to medium spiny neurons in the striatum

Madoka Narushima, Motokazu Uchigashima, Kouichi Hashimoto, Masahiko Watanabe, Masanobu Kano

EUROPEAN JOURNAL OF NEUROSCIENCE, 24(8) 2246-2252, Oct, 2006 Peer-reviewed
Endocannabinoid-mediated short-term suppression of excitatory synaptic transmission to medium spiny neurons in the striatum

M Narushima, K Hashimoto, M Kano

NEUROSCIENCE RESEARCH, 54(3) 159-164, Mar, 2006 Peer-reviewed
In vivo imaging of functional inhibitory networks on the Mauthner cell of larval zebrafish

M Takahashi, M Narushima, Y Oda

JOURNAL OF NEUROSCIENCE, 22(10) 3929-3938, May, 2002 Peer-reviewed

Misc.

Comparison of the role of metabotropic glutamate receptor subtype 1 in developmental refinement of neuronal connectivity between the cerebellum and the sensory thalamus

Madoka Narushima

Neuroscience Research, 129 24-31, Apr, 2018
視床神経回路の感覚経験依存的維持機構の分子基盤

鳴島円, 矢ケ崎有希, 宮田麻理子

東京女子医科大学雑誌, 84(6) 198-198, Dec 25, 2014
発達期における視床皮質連関の機能的意義

鳴島円

上原記念生命科学財団研究報告集, 28 1-4, 2014
Requirement of mGluR1 for Experience-Dependent Remodeling of Mouse Retinogeniculate Synapses

M. Kano, M. Narushima, M. Uchigashima, M. Watanabe, A. Aiba, M. Miyata

CURRENT NEUROPHARMACOLOGY, 12 30-31, 2014
In vivo two-photon imaging analysis of development of direction and orientation selectivity in the mouse visual cortex

Madoka Narushima, Nathalie L. Rochefort, Christine Grienberger, Nima Marandi, Arthur Konnerth

NEUROSCIENCE RESEARCH, 71 E257-E257, 2011
Postnatal development of the lemniscal fiber-relay neuron system in the somatosensory thalamus of mice

Yuichi Takeuchi, Madoka Narushima, Mariko Miyata

NEUROSCIENCE RESEARCH, 71 E260-E260, 2011
Two-photon imaging of orientation and direction selective neurons in the developing mouse visual cortex

Madoka Narushima, Nathalie L. Rochefort, Nima Marandi, Yury Kovalchuk, Arthur Konnerth

NEUROSCIENCE RESEARCH, 65 S25-S26, 2009
Involvement of type 1 metabotoropic glutamate receptor in developmental synapse elimination in the lateral geniculate nucleus

Madoka Narushima, Uchigashima Motokazu, Asami Tanimura, Kouichi Hashimoto, Atsu Aiba, Masahiko Watanabe, Masanobu Kano

NEUROSCIENCE RESEARCH, 61 S57-S57, 2008

Teaching Experience

2021 - Present

血液・循環 (東京医科歯科大学歯学部歯学科（非常勤）)
2021 - Present

脊髄反射機構 (東京医科歯科大学歯学部歯学科（非常勤）)
2014 - 2016

聴覚 (東京女子医科大学医学部)
2014 - 2016

平衡感覚 (東京女子医科大学医学部)
2013 - 2016

味覚・嗅覚 (東京女子医科大学医学部)
2010 - 2016

生理学実習 (東京女子医科大学医学部)
2011 - 2015

解剖生理学 (至誠会看護専門学校（非常勤）)
2015

脊髄反射機構 (東京女子医科大学医学部)

Professional Memberships

Research Projects

Study for presynaptic function in thalamic synapse elimination

Grants-in-Aid for Scientific Research Grant-in-Aid for Transformative Research Areas (A), Grant-in-Aid for Transformative Research Areas (A), Japan Society for the Promotion of Science, Nov, 2020 - Mar, 2025
Experience-dependent plasticity of defensive behaviors to the visual threat and its neural basis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Narushima Madoka
視覚刺激に対する恐怖⾏動のパターン選択における感覚経験の影響とその機構の解明

第15回内藤記念女性研究者研究助成金, 内藤記念科学振興財団, 2020 - 2022

鳴島円
経験依存的大脳皮質入力のスクラップ・アンド・ビルドが恐怖反応に及ぼす影響

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2019 - Mar, 2021

鳴島円
眼球運動に関わる神経回路の発達におけるグリア細胞の役割

第29回加藤記念研究助成, 加藤バイオサイエンス振興財団, 2018 - 2020

鳴島円
正常および発達障害疾患における複数感覚の統合機能の神経基盤解明

平成29年度持田記念研究助成金, 持田記念医学薬学振興財団, 2017 - 2019
Molecular mechanisms for regression of matured synapses as a neuronal basis for Rett syndrome

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

Narushima Madoka
Regulatory role of cortical activity for maintenance of afferent synapses in the sensory thalamus

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2011 - 2013

NARUSHIMA Madoka
内因性カンナビノイドによる大脳基底核の逆行性シナプス伝達調節とその機能的意義

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 2004 - 2005

鳴島円

Profile Information

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Research History

Awards

Papers

Misc.

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