Shuji Kitahara

J-GLOBAL         Last updated: Aug 19, 2019 at 12:11
Shuji Kitahara
Tokyo Women's Medical University
Department of Anatomy
Job title
Senior Lecturer
Ph.D.(Tokyo Women's Medical University)
Other affiliation
Massachusetts General Hospital/Harvard Medical School


I'm a Senior Lecturer (Associate Professor) at Tokyo Women's Medical University (TWMU) since 2018. I graduated from Nippon Dental University in 1999. After graduating, I began to work in the Department of Oral & Maxillofacial surgery at TWMU as an oral surgeon. In 2004, I started a Ph.D. course in the Department of Anatomy and Developmental biology at TWMU. My research hypothesis was that by treating tumor blood vessels and tumor microenvironment, we can reduce tumor volume and we can stop the metastasis. During the Ph.D. course, I had this idea and then I read Dr. Rakesh Jain’s paper on “Normalization of tumor vasculature”, so I was greatly influenced by this paper. To achieve this goal, I joined the Edwin L. Steele Laboratory for training as a postdoctoral fellow. I was working with Drs. Dan G. Duda and Rakesh K. Jain (the Director of the Steele Lab). My goal of this study is to establish this new treatment strategy and to bring it into clinics. Now, I'm striving to develop my academic career as an anatomist with expertise in oncology from a morphological aspect at MGH, HMS, and TWMU. After the end of the study abroad, I returned to TWMU as a faculty. In addition, I'm a manager of “United Japanese Researcher Around The World” which supported by Japan Society for the Promotion of Science (JSPS). And also I organized The Japan-US Science Forum in Boston with JSPS and Japan Forum for Asian Science and Technology (JFAST) with Japan Science and Technology Agency (JST). On the other hand, I'm providing articles about medical science and political science to “WEBRONZA” of Asahi newspaper which is a major Japanese news company. Simultaneously, I'm doing research about political science and health economics as a Ph.D. student at Waseda University.

Research Areas


Academic & Professional Experience

Feb 2018
Senior Lecturer (Associate Professor), Department of Anatomy, Tokyo Women's Medical University
Research Fellow, Department of Radiation Oncology, Massachusetts General Hospital/Harvard Medical School
Institute of Development, Aging and Cancer, Tohoku University
Department of Oral and Maxillofacial Surgery, Medical Center East, Tokyo Women’s Medical University


Waseda University
Hosei University
Post-doc of Tumor Biology, Harvard Medical School
Japan School of Policy Making
Tokyo Women’s Medical University

Awards & Honors

Reserach Award, Nakayama Cancer Institute
Reserach Award, Waseda Medical Academy
14th The Foundation for studying Abroad Program, Mitsukoshi Health And Welfare Foundation
Research Award, Japanese Society for Gastroenterological Carcinogenesis
Travel Award, The Japanese Vascular Biology and Medicine Organization

Published Papers

Shigeta K, Datta M, Hato T, Kitahara S, Chen IX, Matsui A, Kikuchi H, Mamessier E, Aoki S, Ramjiawan RR, Ochiai H, Bardeesy N, Huang P, Jain RK, Cobbold M, Zhu AX, Duda DG
Hepatology (Baltimore, Md.)      Aug 2019   [Refereed]
Kofuji S, Hirayama A, Eberhardt AO, Kawaguchi R, Sugiura Y, Sampetrean O, Ikeda Y, Warren M, Sakamoto N, Kitahara S, Yoshino H, Yamashita D, Sumita K, Wolfe K, Lange L, Ikeda S, Shimada H, Minami N, Malhotra A, Morioka S, Ban Y, Asano M, Flanary VL, Ramkissoon A, Chow LML, Kiyokawa J, Mashimo T, Lucey G, Mareninov S, Ozawa T, Onishi N, Okumura K, Terakawa J, Daikoku T, Wise-Draper T, Majd N, Kofuji K, Sasaki M, Mori M, Kanemura Y, Smith EP, Anastasiou D, Wakimoto H, Holland EC, Yong WH, Horbinski C, Nakano I, DeBerardinis RJ, Bachoo RM, Mischel PS, Yasui W, Suematsu M, Saya H, Soga T, Grummt I, Bierhoff H, Sasaki AT
Nature cell biology   21(8) 1003-1014   Aug 2019   [Refereed]
Role of microenvironment and transient tissue hypoxia in regeneration of the endometrium
Asuka Yoshii, Hisashi Ueta, Shuji Kitahara
Journal of Tokyo Women's Medical University      2019   [Refereed]
How immunotherapy and targeted therapy are changing gastrointestinal cancer treatment.
Shuji Kitahara, Yasuhiro Suzuki, Taichi Ezaki
Med Res Arch      2019   [Refereed][Invited]
Does anti-vascular therapy reprogram the immunosuppressive microenvironment in gastric cancer?
Shuji Kitahara and Yasuhiro Suzuki
Journal of Tokyo Women's Medical University      2019   [Refereed]


肝細胞癌における腫瘍微小環境と腫瘍免疫 免疫治療のメカニズムと治療戦略
茂田 浩平, 松居 彩, Mamessier Emilie, Chen Ivy, 青木 修一, 北原 秀治, 菊池 弘人, 井上 亨悦, 羽藤 泰, Zhu Andrew, Cobbold Mark, Jain Rakesh, Duda Dan, 北川 雄光
日本外科学会定期学術集会抄録集   119回 SF-015   Apr 2019
「リンパ学の明日を探る〜腫瘍学領域」 アジュバント誘導性マウスリンパ管腫モデルにおける腫瘍形成機構
江崎 太一, 清水 一彦, 後原 綾子, 北原 秀治, 佐川 弘美
リンパ学   41(2) 102-106   Dec 2018
留学のすゝめ2018 日本人研究者が世界で活躍するためのプラットフォーム構築に向けて 世界で活躍する女性医師・研究者育成に向けて
北原 秀治, 杉下 智彦, 大黒 史子
日本生化学会大会プログラム・講演要旨集   91回 [1S07p-09]   Sep 2018
宮本 幸子[菊田], 北原 秀治, 森島 正恵, 江崎 太一
東京女子医科大学総合研究所紀要   37 14-15   Mar 2018
中西 秀彦, 北原 秀治, 森島 正恵, 吉井 明日香, 楠田 聡, 江崎 太一
東京女子医科大学総合研究所紀要   37 84-85   Mar 2018

Conference Activities & Talks

Novel approaches to pancreatic cancer [Invited]
Shuji Kitahara
IASGO/Post Graduate Course2019   6 Jul 2019   
Novel Strategies and Approaches for Therapy in Gastrointestinal Tumors [Invited]
Shuji Kitahara
IASGO/Post Graduate Course, Luzhou, China   4 Nov 2017   
Normalizing Tumor Microenvironment to Treat Cancer [Invited]
Shuji Kitahara
The seminar at Tokyo Medical Dental University   4 Apr 2017   
Normalizing Tumor Microenvironment to Treat Cancer in Gastroitestinal Tract [Invited]
Shuji Kitahara
The Annual Meeting of the Japanese Association of Anatomists   30 Mar 2017   
The Cancer Research [Invited]
Shuji Kitahara
Boston Japanese researcher Forum   25 Feb 2017   

Research Grants & Projects

KAKENHI: Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2018 - Mar 2021    Investigator(s): Shuji Kitahara
The Strategy for Normalization of Tumor microenvironment
Fujita Memorial Fund: 
Project Year: 2016 - 2017    Investigator(s): Shuji Kitahara
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(挑戦的萌芽研究)
Project Year: 2012 - 2013    Investigator(s): Taichi EZAKI
We hypothesized that reconstruction of normal blood vessels in tumors may lead to improvement of hypoxic conditions, contributing to potential improvements in the delivery of anticancer drugs. Tumor cells were injected into the dorsal subcutis of ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2010 - 2012    Investigator(s): Shuji KITAHARA
Apc^(Min/+) mice provide a unique orthotopic model for the development of spontaneous adenomatous polyposis and subsequent carcinomas, termed the adenoma-carcinoma sequence. In the current study, we sought to clarify the relationship between the p...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(スタートアップ))
Project Year: 2008 - 2009    Investigator(s): Syuji KITAHARA
We sought to characterize the micro-vascular changes in the intestine of Apc^<Min/+> mice that provide a unique model for the adenomatous polyposis and subsequent carcinoma, namely the adenoma-carcinoma sequence. Remarkable structural changes in t...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2007 - 2009    Investigator(s): Taichi EZAKI
In an adjuvant-induced lymphangioma model, we found that abdominal mesothelial cells and bone marrow-derived cells proliferated and transformed into fat storing cells in response to extrinsic mineral oil, and then, by fusing with each other, forme...

Social Contribution

The 14th Asia Pacific Sociological Association Conference
[Organizing Member]  5 Oct 2018 - 7 Oct 2018
[Advisor, Planner, Investigater, Others]  Cancer X  Cancer X Summit 2019  Oct 2018
Japan Forum for Asian Science and Technology 2017
[Planner, Organizing Member]  3 Dec 2017 - 3 Dec 2017
The Japan-US Science Forum in Boston 2017
[Planner, Organizing Member]  17 Nov 2017 - 17 Nov 2017
研究者 x 高校生-The Science Meeting in Boston-
[Planner, Organizing Member]  23 Mar 2017 - 23 Mar 2017